Journal article
The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma
Oral oncology, v 61, pp 27-30
01 Oct 2016
PMID: 27688101
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Much of the current literature regarding the molecular pathophysiology of human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) has focused on the virus's effect on cell cycle modulation and cell proliferation. A second mechanism of pathogenicity employed by HPV, dysregulation of cellular DNA repair processes, has been more sparsely studied. The purpose of this review is to describe current understanding about the effect of HPV on DNA repair in HNSCC, taking cues from cervical cancer literature. HPV affects DNA-damage response pathways by interacting with many proteins, including ATM, ATR, MRN, gamma-H2AX, Chk1, Chk2, p53, BRCA1, BRCA2, RAD51, Rb-related proteins 107 and 130, Tip60, and p16INK4A. Further elucidation of these pathways could lead to development of targeted therapies and improvement of current treatment protocols. (C) 2016 Elsevier Ltd. All rights reserved.
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Details
- Title
- The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma
- Creators
- Garren M. Low - University of Southern CaliforniaDavid S. Thylur - University of Southern CaliforniaVicky N. Yamamoto - University of Southern CaliforniaUttam K. Sinha - University of Southern California
- Publication Details
- Oral oncology, v 61, pp 27-30
- Publisher
- Elsevier
- Number of pages
- 4
- Grant note
- Watt Family Foundation Wright Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000384695400005
- Scopus ID
- 2-s2.0-84982102694
- Other Identifier
- 991022008088404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Dentistry, Oral Surgery & Medicine
- Oncology