Journal article
The effect of neoadjuvant chemotherapy and surgery in children with malignant germ cell tumors of the genital region: a pediatric intergroup trial
Journal of pediatric surgery, v 38(6), pp 910-912
01 Jun 2003
PMID: 12778391
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study was designed to evaluate (1) the efficacy of standard or high-dose cisplatin with etoposide and bleomycin and (2) the role of surgical resection in infants and children with malignant germ cell tumors (MGCT) of the genital region.
Fourteen of 317 children enrolled in to the Pediatric Oncology Group/Children’s Cancer Group intergroup study of MGCT from 1990 through 1996 had genital tumors. Thirteen were eligible for inclusion (12 vaginal, one penile). The initial procedure was biopsy in 11 and subtotal resection in 2. Patients were assigned randomly to receive 4 cycles of etoposide, bleomycin, and either standard or high-dose cisplatin.
Nine children underwent postchemotherapy excision of the residual site, and 2 had subsequent biopsies to confirm a complete response. Two with relapse were saved with additional therapy, and one with progressive disease died. The 4-year event-free survival rate in these patients is 76.2% ± 13.1%, and 4-year survival rate is 91.7% ± 8.4%.
The author conclude that: (1) the current survival rate for genital MGCT is excellent, (2) delayed surgical resection with organ preservation is not associated with an adverse outcome, and (3) the treatment comparison of the effect of cisplatin dose was inconclusive in this small study population.
Metrics
Details
- Title
- The effect of neoadjuvant chemotherapy and surgery in children with malignant germ cell tumors of the genital region: a pediatric intergroup trial
- Creators
- Frederick Rescorla - Indiana University School of Medicine, Indianapolis, IN, USADeborah Billmire - Indiana University School of Medicine, Indianapolis, IN, USACharles Vinocur - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)Paul Colombani - Johns Hopkins School of Medicine, Baltimore, MD, USAWendy London - Childrens Oncology Group Statistical Office, Gainesville, FL, USARoger Giller - The Childrens Hospital, Denver, CO, USABarbara Cushing - Wayne State University, Detroit, MI, USAStephen Lauer - Emory University School of Medicine, Atlanta, GA, USAJohn Cullen - Presbyterian St. Luke's Medical CenterEdith Hawkins - Texas Childrens Hospital, Houston, TX, USA
- Publication Details
- Journal of pediatric surgery, v 38(6), pp 910-912
- Publisher
- Elsevier
- Number of pages
- 3
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Web of Science ID
- WOS:000183555900029
- Scopus ID
- 2-s2.0-0038657976
- Other Identifier
- 991019168214404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics
- Surgery