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The effect of protein-free versus protein-containing medium on the mechanical properties and uptake of ions of PVA/PVP hydrogels
Journal article   Peer reviewed

The effect of protein-free versus protein-containing medium on the mechanical properties and uptake of ions of PVA/PVP hydrogels

Garland Fussell, Jonathan Thomas, Justin l Scanlon, Anthony Lowman and Michele Marcolongo
Journal of biomaterials science. Polymer ed, v 16(4), pp 489-503
2005
DOI: https://doi.org/10.1163/1568562053700219
PMID: 15887655
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Biocompatible Materials - chemistry Chlorine - chemistry Culture Media - chemistry Hydrogel, Polyethylene Glycol Dimethacrylate Hydrogels - chemistry Ions Materials Testing Polymers - chemistry Polyvinyl Alcohol - chemistry Povidone - chemistry Proteins - chemistry Stress, Mechanical Tensile Strength Time Factors
The effect of two simulated biological environments (protein-free and protein-containing) on ion uptake and physical properties of PVA/PVP hydrogels were explored in this work. It was found that over the immersion period in both media, wet mass of the hydrogels decreased and compressive moduli increased, likely due to increased polymer content with water loss as the hydrogels equilibrated with water. These changes were independent of polymer content and immersion medium. However, dry mass of the hydrogels increased dramatically when immersed in protein-free medium, changing only moderately in protein-containing medium. The increase in dry mass was attributed to ion uptake from immersion medium, as confirmed by EDXA. We postulate that differences between ion uptake in protein-free versus protein-containing medium is likely the result of serum proteins in the protein-containing medium adsorbing to the surface, inhibiting transport of ions into the hydrogel.

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29 citations in Web of Science
29 citations in Scopus

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Web of Science research areas
Engineering, Biomedical
Materials Science, Biomaterials
Polymer Science
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