Journal article
The effect of renal function on enalapril kinetics
Clinical pharmacology and therapeutics, v 38(6), pp 661-666
Dec 1985
PMID: 2998676
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Enalapril maleate (MK‐421), a nonmercapto‐containing angiotensin converting enzyme (ACE) inhibitor, is converted in vivo to enalaprilat (MK‐422), the active diacid. We evaluated serum profiles and urinary excretion of oral enalapril maleate in patients with renal disease (group I, creatinine clearance <3 ml/ min, patients undergoing dialysis, n = 10; group II, creatinine clearance 10 to 79 ml/min, n = 9) compared with healthy subjects (group III, creatinine clearance >80 ml/min, n = 10). Group I received a 10 mg dose during a day while not receiving dialysis and a 10 mg dose 1 hour before dialysis 2 weeks later. Groups II and III received a single 10 mg dose. Blood samples and urine were collected for 48 hours. Impaired renal function resulted in elevated serum and plasma concentrations of enalapril maleate and decreased excretion rates and urinary recovery of enalapril maleate and enalaprilat. The data suggest an apparent increase in the extent of metabolism of enalapril maleate to enalaprilat or an increase in nonrenal elimination of unchanged enalapril maleate in renal disease compared with normal health. Enalaprilat was dialyzable.
Clinical Pharmacology and Therapeutics (1985) 38, 661–666; doi:10.1038/clpt.1985.242
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Details
- Title
- The effect of renal function on enalapril kinetics
- Creators
- D T Lowenthal - Hahnemann University HospitalJ D Irvin - Hahnemann University HospitalD Merrill - Hahnemann University HospitalS Saris - Hahnemann University HospitalE Ulm - Hahnemann University HospitalS Goldstein - Hahnemann University HospitalM Hichens - Hahnemann University HospitalL Klein - Hahnemann University HospitalA Till - Hahnemann University HospitalK Harris - Hahnemann University Hospital
- Publication Details
- Clinical pharmacology and therapeutics, v 38(6), pp 661-666
- Publisher
- Springer Nature
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Finance
- Web of Science ID
- WOS:A1985AWQ5100010
- Scopus ID
- 2-s2.0-0022396526
- Other Identifier
- 991019184299804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy