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The effects of cocaine exposure prior to and during pregnancy in rats fed low or adequate protein diets
Journal article   Open access   Peer reviewed

The effects of cocaine exposure prior to and during pregnancy in rats fed low or adequate protein diets

John Tonkiss, Penny L Shultz, Jed S Shumsky, Susan J Blease, Thomas L Kemper and Janina R Galler
Neurotoxicology and teratology, v 17(5), pp 593-600
1995
DOI: https://doi.org/10.1016/0892-0362(95)00020-R
PMID: 8552006
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/0892-0362(95)00020-RView
Published, Version of Record (VoR) Open

Abstract

Pregnancy Prenatal Skeletal maturation Rat Food intake Pregnancy outcome Cocaine Gestation Malnutrition Weight gain
Sprague-Dawley rats were fed a diet of low protein content (6% casein), an isocaloric diet of adequate protein content (25% casein), or a laboratory chow diet for 5 weeks prior to mating and throughout pregnancy. Within each diet group, rats received either cocaine (30 mg/kg IP two times per week prior to mating and 30 mg/kg or 40 mg/ kg SC daily from days 3 to 18 of pregnancy) or saline injections. Cocaine produced a greater reduction in food intake during pregnancy in the malnourished group compared with the other two diet groups. The effect of cocaine on food intake was minimal in chow-fed rats. Weight gain in pregnancy was reduced by cocaine in a dose-dependent manner, and by malnutrition. Both prenatal cocaine and malnutrition impaired skeletal maturation of the pups, but there was no additive effect of the two insults on this measure. Litter size was significantly reduced by the 40 mg/kg, but not by the 30 mg/kg dose of cocaine across all diet groups. Consequently, the 40 mg/kg dose of cocaine proved to be fetotoxic in this model. Birth weight was significantly reduced by prenatal malnutrition but not by prenatal cocaine. Gestation length was unaffected by either insult. Hence, the ability to detect a diet × drug interaction was dependent upon the variable being measured.

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Web of Science research areas
Neurosciences
Toxicology
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