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The effects of epileptic cortical activity on the development of callosal projections
Journal article   Peer reviewed

The effects of epileptic cortical activity on the development of callosal projections

Antony M. Grigonis and E. Hazel Murphy
Brain research. Developmental brain research, v 77(2)
1994
DOI: https://doi.org/10.1016/0165-3806(94)90200-3
PMID: 8174232
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Corpus callosum Development Epilepsy Neural activity
The effect of epileptic neural activity on the postnatal development of the corpus callosum was studied. Epileptiform activity was induced in the visual cortex of postnatal rabbits by continuous infusion of penicillin. Callosal projections of the occipital cortex were studied in rabbits aged at least 4 weeks. In these penicillin-exposed rabbits, the visual callosal projections extended through most of area 17 in a projection pattern characteristic of neonatal rabbits, rather than being restricted to a narrow callosal zone at the lateral border of area 17, as they usually are by this age. The results indicate that epileptic cortical activity stabilizes immature callosal projections which are normally eliminated during development. The maintenance of such immature and non-specific projections in the mature CNS may interfere with normal cortical functions and could underlie the cognitive deficits which have been observed following childhood epilepsy.

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Web of Science research areas
Developmental Biology
Neurosciences
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