Journal article
The effects of ligands on enzymic carboxyl-methylation of neurophysins
Biochemical and biophysical research communications, v 73(4), pp 1063-1067
1976
PMID: 15625882
Abstract
The methyl-acceptor activities of bovine neurophysins I and II for the enzyme protein carboxymethylase (EC 2.1.1.24) were found to be similar and as high as for other previously identified, biologically active protein substrates. Effects on the rate of methylation of these neurophysins were investigated with the posterior pituitary hormone ligands, oxytocin and vasopressin, and the hormone-related tripeptide ligand, methionyl-tyrosylphenylalaninamide. An increase in the rate of neurophysin II methylation was observed with both oxytocin and tripeptide. This ligand-induced response did not occur with either native neurophysin I or disulfide-scrambled neurophysin II.
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Details
- Title
- The effects of ligands on enzymic carboxyl-methylation of neurophysins
- Creators
- Emanuel J. Diliberto - National Institute of Mental HealthJulius Axelrod - National Institute of Mental HealthIrwin M. Chaiken - National Institute of Mental Health
- Publication Details
- Biochemical and biophysical research communications, v 73(4), pp 1063-1067
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Drexel University
- Web of Science ID
- WOS:A1976CR19200034
- Scopus ID
- 2-s2.0-0017059232
- Other Identifier
- 991019520536804721