Journal article
The effects of limb laterality and age on the inflammation and bone turnover of the acromioclavicular shoulder joint: F-18-fluorodeoxyglucose and F-18-sodium-fluoride-PET/computed tomography study
Nuclear medicine communications, v 43(8), pp 922-927
01 Aug 2022
PMID: 35634806
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose The acromioclavicular (AC) joint is a common site of injury and degenerative changes such as osteoarthritis (OA) of the shoulder. Physical manifestations of OA are preceded by molecular changes, detection of which may enhance early prophylaxis and monitoring of disease progression. In this study, we investigate the use of F-18-FDG and F-18-NaF-PET/CT to assess the effects of limb laterality and age on the inflammation and bone turnover of the AC shoulder joint. Methods We analyzed FDG and NaF-PET/CT scans of 41 females (mean age of 43.9 +/- 14.2 years) and 45 males (mean age of 44.5 +/- 13.8 years) using a semiquantitative technique based on predefined ROI. Results There was a greater NaF uptake in the right side of the AC joint compared with the left in both females (left: 2.22 +/- 1.00; right: 3.08 +/- 1.18; P < 0.0001) and males (left: 2.57 +/- 1.49; right: 2.99 +/- 1.40; P = 0.003). No consistent correlation between age and NaF or FDG uptakes were found in both females and males. There was also a positive correlation between FDG and NaF uptakes in both left (P = 0.01; r = 0.37) and right (P = 0.0006; r = 0.53) AC joints of male subjects. Conclusion Our study is the first to reveal the varying effect of right-left limb laterality and aging on FDG and NaF uptake at the AC joint. Future studies correlating the history of shoulder trauma, pain, and degenerative change with FDG and NaF-PET/CT findings will be critical in the adoption of molecular imaging in the clinical setting.
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Details
- Title
- The effects of limb laterality and age on the inflammation and bone turnover of the acromioclavicular shoulder joint: F-18-fluorodeoxyglucose and F-18-sodium-fluoride-PET/computed tomography study
- Creators
- Peter Sang Uk Park - Hospital of the University of PennsylvaniaElysia McDonald - Hospital of the University of PennsylvaniaShashi Bhushan Singh - Hosp Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USAWilliam Y. Raynor - Drexel University, Radiology (Radiologic Sciences)Thomas J. Werner - Hospital of the University of PennsylvaniaPoul Flemming Hoilund-Carlsen - College Station Medical CenterAbass Alavi - University of Pennsylvania
- Publication Details
- Nuclear medicine communications, v 43(8), pp 922-927
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000825138600010
- Scopus ID
- 2-s2.0-85134428374
- Other Identifier
- 991019350663004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging