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Accepted (AM)Open Access (License Unspecified), Open
Journal article
The effects of prenatal cocaine exposure and gender on inhibitory control and attention
Neurotoxicology and teratology, v 33(1), pp 61-68
01 Jan 2011
PMID: 21256425
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Children exposed prenatally to cocaine show deficits in emotion regulation and inhibitory control. While controlling for the measures of medical complication in the perinatal period, environmental risk, and prenatal polydrug exposure (alcohol, tobacco, and marijuana), we examined the effects of prenatal cocaine exposure and gender on attention and inhibitory control in 203 children at ages 6, 9, and 11. Cocaine exposure affected the performance of males, but not females. Heavily exposed males showed deficits in the attention and the inhibition tasks. In addition, a significantly greater proportion of heavily exposed males (21%) than unexposed males (7%) or heavily exposed females (7%) failed to complete the task (p<0.01). Even without those poorest performing subjects, the overall accuracy for heavily exposed males (81%) was significantly reduced (p<0.05) compared to lightly exposed males (87%) and unexposed males (89%). The findings highlight the importance of considering gender specificity in cocaine exposure effects. Processes by which cocaine effects may be specific to males are discussed. (C) 2010 Elsevier Inc. All rights reserved.
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Details
- Title
- The effects of prenatal cocaine exposure and gender on inhibitory control and attention
- Creators
- Dennis P. Carmody - University of Medicine and Dentistry of New JerseyDavid S. Bennett - Drexel UniversityMichael Lewis - University of Medicine and Dentistry of New Jersey
- Publication Details
- Neurotoxicology and teratology, v 33(1), pp 61-68
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- R01DA007109 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission USPHS R01-DA07109 / National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000287609800008
- Scopus ID
- 2-s2.0-78751515321
- Other Identifier
- 991019168898004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Toxicology