Journal article
The effects of reserpine upon body weight, brain weight and brain indoleamine stores in maturing mice
General pharmacology, v 10(3), pp 233-237
1979
PMID: 467962
Abstract
1.
1. Mice of 1 day, 1 week, 2 weeks, and 6 weeks of age have been injected with the amine depletor reserpine and then measured for changes in body weight, brain weight, and indoleamine stores.
2.
2. Immature mice showed a transient loss of brain weight and a long term loss of body weight.
3.
3. Onset of drug action as reflected in the brains 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) stores was slower in 1 day olds than in later ages.
4.
4. Recovery of 5-HT levels was faster in younger mice while recovery of 5-HIAA levels was faster in older animals.
5.
5. It is suggested that 5-HT recovery is related to differences in 5-HT synthesis at various ages and 5-HIAA recovery is related to the maturity of the brain's acid transport system.
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Details
- Title
- The effects of reserpine upon body weight, brain weight and brain indoleamine stores in maturing mice
- Creators
- Peter C. Baker - Cleveland State UniversityKenneth M. Hoff - Cleveland State UniversityCecilie A. Goodrich - Cleveland State University
- Publication Details
- General pharmacology, v 10(3), pp 233-237
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1979HA38100014
- Scopus ID
- 2-s2.0-0018775367
- Other Identifier
- 991021463666904721