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Journal article
The emerging role of positron emission tomography (PET) in the management of photon radiotherapy-induced vasculitis in head and neck cancer patients
Clinical and translational imaging : reviews in nuclear medicine and molecular imaging
17 Feb 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose
While radiotherapy (RT) for head and neck cancer (HNC) has made recent strides, RT-induced vasculitis continues to adversely affect long-term patient outcomes. Guidelines for managing this complication remain scarce, supporting the need for a sensitive imaging modality in post-treatment evaluations. In this review, we discuss the current literature regarding F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) and F-18-sodium fluoride (NaF-PET) in evaluating RT-induced vasculitis in HNC patients, highlighting several arenas of evolving clinical significance: (1) early recognition and standardized evaluation of RT-induced vasculitis, and (2) potential for a multifaceted diagnostic tool to stratify cardiovascular risk in HNC patients.
Methods
Numerous databases, including, but not limited to, Google Scholar and PubMed, were utilized to compile a body of literature regarding PET imaging of RT-induced vasculitis in HNC and related malignancies.
Results
Multiple studies have established the clinical capabilities of FDG-PET/computed tomography (FDG-PET/CT) for detection and management of RT-induced vasculitis in HNC patients, while NaF-PET/CT remains under investigation. Inflammatory vascular stages may be best analyzed by FDG-PET/CT, while vascular microcalcification and atherosclerotic disease may be supplementally assessed by the unique properties of NaF-PET/CT. With these modalities detecting primary stages of more detrimental vascular complications, PET imaging may carry several advantages over conventional, structural techniques.
Conclusion
FDG-PET/CT and NaF-PET/CT hold significant potential as preliminary diagnostic tools in monitoring early inflammation and atherosclerotic plaque development, warranting further research and attention. Applying these techniques in this context may foster proactive and consistent assessments of RT-induced vasculitis in HNC patients, mitigating potential cardiovascular risks through better-informed treatment decisions.
Metrics
Details
- Title
- The emerging role of positron emission tomography (PET) in the management of photon radiotherapy-induced vasculitis in head and neck cancer patients
- Creators
- Allegra Delman - Drexel UniversityMatthew T. Griffin - Drexel UniversityThomas J. Werner - University of PennsylvaniaAbass Alavi - University of PennsylvaniaWilliam Y. Raynor - University of PennsylvaniaMona-Elisabeth Revheim (Corresponding Author) - College Station Medical Center
- Publication Details
- Clinical and translational imaging : reviews in nuclear medicine and molecular imaging
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- Oslo University Hospital University of Oslo
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000939495100001
- Scopus ID
- 2-s2.0-85148064271
- Other Identifier
- 991020237343904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging