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Journal article
The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module
Cancer research (Chicago, Ill.), v 75(10), pp 1992-2004
15 May 2015
PMID: 25769723
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prostate cancer is the second leading form of cancer-related death in men. In a subset of prostate cancer patients, increased chemokine signaling IL8 and IL6 correlates with castrate-resistant prostate cancer (CRPC). IL8 and IL6 are produced by prostate epithelial cells and promote prostate cancer cell invasion; however, the mechanisms restraining prostate epithelial cell cytokine secretion are poorly understood. Herein, the cell-fate determinant factor DACH1 inhibited CRPC tumor growth in mice. Using Dach1(fl/fl)/Probasin-Cre bitransgenic mice, we show IL8 and IL6 secretion was altered by approximately 1,000-fold by endogenous Dach1. Endogenous Dach1 is shown to serve as a key endogenous restraint to prostate epithelial cell growth and restrains migration via CXCL signaling. DACH1 inhibited expression, transcription, and secretion of the CXCL genes (IL8 and IL6) by binding to their promoter regulatory regions in chromatin. DACH1 is thus a newly defined determinant of benign and malignant prostate epithelium cellular growth, migration, and cytokine abundance in vivo.
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Details
- Title
- The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module
- Creators
- Ke Chen - Thomas Jefferson UniversityKongming Wu - Thomas Jefferson UniversityXuanmao Jiao - Thomas Jefferson UniversityLiping Wang - Thomas Jefferson UniversityXiaoming Ju - Thomas Jefferson UniversityMin Wang - Thomas Jefferson UniversityGabriele Di Sante - Thomas Jefferson UniversityShaohua Xu - Thomas Jefferson UniversityQiong Wang - Thomas Jefferson UniversityKevin Li - Thomas Jefferson UniversityXin Sun - Thomas Jefferson UniversityCongwen Xu - Thomas Jefferson UniversityZhiping Li - Thomas Jefferson UniversityMathew C Casimiro - Thomas Jefferson UniversityAdam Ertel - Thomas Jefferson UniversitySankar Addya - Thomas Jefferson UniversityPeter A McCue - Thomas Jefferson UniversityMichael P Lisanti - Thomas Jefferson UniversityChenguang Wang - Thomas Jefferson UniversityRichard J Davis - Neural Stem Cell InstituteGraeme Mardon - Baylor College of MedicineRichard G Pestell - Thomas Jefferson University
- Publication Details
- Cancer research (Chicago, Ill.), v 75(10), pp 1992-2004
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- R01CA137494 / NCI NIH HHS R01 CA075503 / NCI NIH HHS R01CA070896 / NCI NIH HHS R01 CA086072 / NCI NIH HHS R01 CA137494 / NCI NIH HHS P30CA56036 / NCI NIH HHS R01CA086072 / NCI NIH HHS R01 CA070896 / NCI NIH HHS P30 CA056036 / NCI NIH HHS F31 CA171594 / NCI NIH HHS R01CA075503 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000357332700009
- Scopus ID
- 2-s2.0-84942920010
- Other Identifier
- 991019176645804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology