Journal article
The genomic basis of environmental adaptation in house mice
PLoS genetics, v 14(9), pp e1007672-e1007672
24 Sep 2018
PMID: 30248095
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
House mice (Mus musculus) arrived in the Americas only recently in association with European colonization (~400-600 generations), but have spread rapidly and show evidence of local adaptation. Here, we take advantage of this genetic model system to investigate the genomic basis of environmental adaptation in house mice. First, we documented clinal patterns of phenotypic variation in 50 wild-caught mice from a latitudinal transect in Eastern North America. Next, we found that progeny of mice from different latitudes, raised in a common laboratory environment, displayed differences in a number of complex traits related to fitness. Consistent with Bergmann's rule, mice from higher latitudes were larger and fatter than mice from lower latitudes. They also built bigger nests and differed in aspects of blood chemistry related to metabolism. Then, combining exomic, genomic, and transcriptomic data, we identified specific candidate genes underlying adaptive variation. In particular, we defined a short list of genes with cis-eQTL that were identified as candidates in exomic and genomic analyses, all of which have known ties to phenotypes that vary among the studied populations. Thus, wild mice and the newly developed strains represent a valuable resource for future study of the links between genetic variation, phenotypic variation, and climate.
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Details
- Title
- The genomic basis of environmental adaptation in house mice
- Creators
- Megan Phifer-Rixey - University of California, BerkeleyKe Bi - QB3Kathleen G Ferris - Museum of Vertebrate ZoologyMichael J Sheehan - Cornell UniversityDana Lin - University of California, BerkeleyKatya L Mack - Museum of Vertebrate ZoologySara M Keeble - University of MontanaTaichi A Suzuki - University of California, BerkeleyJeffrey M Good - University of MontanaMichael W Nachman - Museum of Vertebrate Zoology
- Publication Details
- PLoS genetics, v 14(9), pp e1007672-e1007672
- Publisher
- Public LIbrary of Science (PLOS)
- Grant note
- R01 HD073439 / NICHD NIH HHS R01 GM098536 / NIGMS NIH HHS R01 GM074245 / NIGMS NIH HHS S10 OD018174 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000446157400039
- Scopus ID
- 2-s2.0-85054465017
- Other Identifier
- 991021229989404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity