Journal article
The heterogeneity of mild cognitive impairment: A neuropsychological analysis
Journal of the International Neuropsychological Society, v 16(1)
01 Jan 2010
PMID: 19887015
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A group of 94 nondemented patients self-referred to an outpatient memory clinic for memory difficulties were Studied to determine the incidence of single versus multi-domain mild cognitive impairment, (MCI) using Petersen criteria. Fifty-five community dwelling normal controls (NC) participants without memory complaints also were recruited. Tests assessing executive control, naming/lexical retrieval. and declarative memory were administered. Thirty-four patients exhibited single-domain MCI. 43 patients presented with multi-domain MCI. When the entire MCI sample (n = 77) was Subjected to a Cluster analysis, 14 patients were classified with amnesic MCI. 21 patients with dysexecutive MCI, and 42 patients were classified into a mixed/multi-domain MCI group involving low scores oil tests of letter fluency, "animal" fluency, and delayed recognition discriminability. Analyses comparing the three cluster-derived MCI groups versus a NC group confirmed the presence of memory and dysexecutive impairment for the amnesic and dysexecutive MCI groups. The mixed MCI group produced lower scores on tests of letter fluency compared with the amnesic MCI and NC groups and lower scores on tests of naming and memory compared with the NC group. In summary, multi-domain MCI is quite common. These data suggest that MCI is a highly nuanced and complex clinical entity. (JINS, 2010, 16, 84-93.)
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Details
- Title
- The heterogeneity of mild cognitive impairment: A neuropsychological analysis
- Creators
- David J. Libon - Drexel UniversitySharon X. Xie - University of PennsylvaniaJoel Eppig - Drexel UniversityGraham Wicas - Drexel UniversityMelissa Lamar - King's College LondonCarol Lippa - Drexel UniversityBrianne M. Bettcher - Temple UniversityCatherine C. Price - University of Florida HealthTania Giovannetti - Temple UniversityRod Swenson - North Dakota State UniversityDenene M. Wambach - Drexel University
- Publication Details
- Journal of the International Neuropsychological Society, v 16(1)
- Publisher
- Cambridge Univ Press
- Number of pages
- 10
- Grant note
- K23NS060660 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000273579600010
- Scopus ID
- 2-s2.0-77149133072
- Other Identifier
- 991019312464504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Psychiatry
- Psychology