Journal article
The iddm4 Locus Segregates With Diabetes Susceptibility in Congenic WF.iddm4 Rats
Diabetes (New York, N.Y.), v 51(11), pp 3254-3262
Nov 2002
PMID: 12401717
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Viral antibody–free BBDR and WF rats never develop spontaneous diabetes. BBDR rats, however, develop autoimmune diabetes after perturbation of the immune system, e.g., by viral infection. We previously identified a disease-susceptibility locus in the BBDR rat,
iddm4
, which is associated with the development of autoimmune diabetes after treatment with polyinosinic:polycytidylic acid and an antibody that depletes ART2
+
regulatory cells. We have now developed lines of congenic WF.
iddm4
rats and report that in an intercross of N5 generation WF.
iddm4
rats, ∼70% of animals either homozygous or heterozygous for the BBDR origin allele of
iddm4
became hyperglycemic after treatment to induce diabetes. Fewer than 20% of rats expressing the WF origin allele of
iddm4
became diabetic. Testing the progeny of various recombinant N5 WF.
iddm4
congenic rats for susceptibility to diabetes suggests that
iddm4
is centered on a small segment of chromosome 4 bounded by the proximal marker
D4Rat135
and the distal marker
D4Got51
, an interval of <2.8 cM. The allele at
iddm4
has 79% sensitivity and 80% specificity in prediction of diabetes in rats that are segregating for this locus. These characteristics suggest that
iddm4
is one of the most powerful non–major histocompatibility complex determinants of susceptibility to autoimmune diabetes described to date.
Metrics
Details
- Title
- The iddm4 Locus Segregates With Diabetes Susceptibility in Congenic WF.iddm4 Rats
- Creators
- John P Mordes - Department of Medicine, University of Massachusetts Medical School, Worcester, MassachusettsJean Leif - Department of Medicine, University of Massachusetts Medical School, Worcester, MassachusettsStephen Novak - Department of Microbiology and Immunology, MCP Hahnemann University, Philadelphia, PennsylvaniaCheryl DeScipio - Department of Microbiology and Immunology, MCP Hahnemann University, Philadelphia, PennsylvaniaDale L Greiner - Department of Medicine, University of Massachusetts Medical School, Worcester, MassachusettsElizabeth P Blankenhorn - Department of Microbiology and Immunology, MCP Hahnemann University, Philadelphia, Pennsylvania
- Publication Details
- Diabetes (New York, N.Y.), v 51(11), pp 3254-3262
- Publisher
- American Diabetes Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000178914900014
- Scopus ID
- 2-s2.0-0036829917
- Other Identifier
- 991014878487904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism