Journal article
The impact of immuno-aging on SARS-CoV-2 vaccine development
GeroScience, v 43(1), pp 1-21
11 Feb 2021
PMID: 33569701
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The SARS-CoV-2 pandemic has almost 56 million confirmed cases resulting in over 1.3 million deaths as of November 2020. This infection has proved more deadly to older adults (those >65 years of age) and those with immunocompromising conditions. The worldwide population aged 65 years and older is increasing, and the total number of aged individuals will outnumber those younger than 65 years by the year 2050. Aging is associated with a decline in immune function and chronic activation of inflammation that contributes to enhanced viral susceptibility and reduced responses to vaccination. Here we briefly review the pathogenicity of the virus, epidemiology and clinical response, and the underlying mechanisms of human aging in improving vaccination. We review current methods to improve vaccination in the older adults using novel vaccine platforms and adjuvant systems. We conclude by summarizing the existing clinical trials for a SARS-CoV-2 vaccine and discussing how to address the unique challenges for vaccine development presented with an aging immune system.
Metrics
Details
- Title
- The impact of immuno-aging on SARS-CoV-2 vaccine development
- Creators
- Jennifer Connors - Drexel UniversityMatthew R. Bell - Drexel UniversityJennifer Marcy - Drexel UniversityMichele Kutzler - Drexel UniversityElias K. Haddad - Drexel University
- Publication Details
- GeroScience, v 43(1), pp 1-21
- Publisher
- Springer International Publishing
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Medicine (Graduate); Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000616934300001
- Scopus ID
- 2-s2.0-85100823670
- Other Identifier
- 991019167626704721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Geriatrics & Gerontology