Journal article
The impact of region-specific leukoaraiosis on working memory deficits in dementia
Neuropsychologia, v 46(10), pp 2597-2601
01 Aug 2008
PMID: 18501390
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
MRI leukoaraiosis (LA) is less likely to interfere with simple compared to more complex working memory (WM) skills. We hypothesize that LA within the left hemisphere negatively impacts higher-level WM processes in dementia. Participants with dementia (n = 64; MMSE = 22.0 +/- 3.4) performed a Backward Digit Task measuring simple storage/rehearsal (ANY-ORDER) and complex disengagement/temporal re-ordering (SERIAL-ORDER) recall. A visual rating scale categorized MRI-LA in five regions per hemisphere: frontal and parietal centrum semiovale, white matter around the frontal horns, body of the lateral ventricles and posterior horns. Amidst equivalent hemispheric LA scores [t(62) = -1.12, p > 0.05], correlations revealed an association between left-sided LA and SERIAL-ORDER recall (r = -0.31, p = 0.007) with LA around the posterior horn (rho = -0.30, p = 0.008) and frontal centrum semiovale (rho = -0.29, p = 0.01) showing the greatest association. Regression modeling confirmed the left posterior horn contribution to SERIAL-ORDER performance variance. Results suggest involvement of anterior (fronto-striatal) and more posterior (inferior parietal) white matter tracts in higher order WM deficits in dementia. (C) 2008 Elsevier Ltd. All rights reserved.
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Details
- Title
- The impact of region-specific leukoaraiosis on working memory deficits in dementia
- Creators
- Melissa Lamar - King's College LondonMarco Catani - College Station Medical CenterCatherine C. Price - Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32611 USAKenneth M. Heilman - Univ Florida, Dept Neurol, Gainesville, FL 32611 USADavid J. Libon - Drexel University
- Publication Details
- Neuropsychologia, v 46(10), pp 2597-2601
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- R01NS082386 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) K23 NS060660; R01 NS082386 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000257679100016
- Scopus ID
- 2-s2.0-44649122697
- Other Identifier
- 991021901012804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Psychology, Experimental