Journal article
The impact of sex on risk of cardiovascular disease and all-cause mortality in adults with or without diabetes mellitus: A comparison between the US and Japan
Journal of diabetes and its complications, v 33(6), pp 417-423
01 Jun 2019
PMID: 31003923
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aims: To test a hypothesis that women with diabetes mellitus (DM) versus those without DM had a significantly higher risk of heart disease (HD), stroke and all-cause mortality than their male counterparts in the U.S. as well as in Japan.
Methods: We analyzed two nationally representative datasets, one from the U.S. NI-lANES III cohort (n = 13,169), and the other from the Japan NIPPON DATA90 cohort (n = 7445). Hazard ratios (HRs) of DM for risk of mortality and sex-DM interaction effect on mortality were analyzed prospectively using Cox's proportional hazards regression models.
Results: Patients with DM had significantly higher mortality from HD, stroke and all-cause mortality in the U.S. and in Japan. However, the HRs of DM versus non-DM for HD and all-cause mortality were significantly higher in women compared to men in the U.S. (sex-DM interaction: HR = 1.59, p = 0.01, and 124, p = 0.045 for HD and all-cause mortality), but the sex-DM interaction effect was not statistically significant in the Japanese cohort.
Discussion: Patients with DM had a significantly higher risk of mortality than those without DM in the U.S. and Japan. However, women with DM versus those without DM had a higher relative risk of HD and all-cause mortality than their counterparts in men in the U.S, but this sex difference by DM status was not observed in the Japanese cohort. Whether the sex-difference effect of DM on HD and all-cause mortality is due to a difference in metabolic disorders between the two populations warrants consideration and further studies. (C) 2019 Elsevier Inc. All rights reserved.
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Details
- Title
- The impact of sex on risk of cardiovascular disease and all-cause mortality in adults with or without diabetes mellitus: A comparison between the US and Japan
- Creators
- Longjian Liu - Drexel UniversityKatsuyuki Miura - Shiga University of Medical ScienceAya Kadota - Shiga University of Medical ScienceAkira Fujiyoshi - Shiga University of Medical ScienceEdward J. Gracely - Drexel UniversityFuzhong Xue - Shandong UniversityZuolu Liu - University of California, Los AngelesNaoyuki Takashima - Shiga University of Medical ScienceNaoko Miyagawa - Shiga University of Medical ScienceTakayoshi Ohkubo - Teikyo UniversityHisatomi Arima - Fukuoka UniversityAkira Okayama - Research Institute of Strategy for Prevention, Tokyo, Japan.Tomonori Okamura - Keio UniversityHirotsugu Ueshima - Shiga University of Medical Science
- Publication Details
- Journal of diabetes and its complications, v 33(6), pp 417-423
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- 7A-2; H11-Chouju-046; H14-Chouju-003; H17-Chouju-012; H19-Chouju-Ippan-0141; H22-Junkankitou-Seishuu-Sitei017; H25-Junkankitou-Seishuu-Sitei-022; H30-Junkankitou-Sitei-002 / Ministry of Health, Labour and Welfare, and Health and Labour Sciences Research Grants, Japan Ministry of Health, Labour and Welfare under the auspices of the Japanese Association for Cerebro-cardiovascular Disease Control
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000469522700003
- Scopus ID
- 2-s2.0-85064270202
- Other Identifier
- 991019168383604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism