Journal article
The importance of nomenclature for congenital cardiac disease: implications for research and evaluation
Cardiology in the young, v 18(S2), pp 92-100
01 Dec 2008
PMID: 19063779
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Administrative databases are often used for congenital cardiac disease research and evaluation, with little validation of the accuracy of the diagnostic codes. Methods: Metropolitan Atlanta Congenital Defects Program surveillance records were reviewed and classified using a version of the International Pediatric and Congenital Cardiac Code. Using this clinical nomenclature as the referent, we report the sensitivity and false positive fraction (1 - positive predictive value) of the International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes for tetralogy of Fallot, transposition of the great arteries, and hypoplastic left heart syndrome. Results: We identified 4918 infants and foetuses with congenital cardiac disease from the surveillance records. Using only the International Classification of Diseases diagnosis codes, there were 280 records with tetralogy, 317 records with transposition, and 192 records with hypoplastic left heart syndrome. Based on the International Pediatric and Congenital Cardiac Code, 330 records were classified as tetralogy, 163 records as transposition, and 179 records as hypoplastic left heart syndrome. The sensitivity of International Classification of Diseases diagnosis codes was 83% for tetralogy, 100% for transposition, and 95% for hypoplastic left heart syndrome. The false positive fraction was 2% for tetralogy, 49% for transposition, and 1196 for hypoplastic left heart syndrome. Conclusions: Analyses based on International Classification of Diseases diagnosis codes may have substantial misclassification of congenital heart disease. Isolating the major defect is difficult, and certain codes do not differentiate between variants that are clinically and developmentally different.
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Details
- Title
- The importance of nomenclature for congenital cardiac disease: implications for research and evaluation
- Creators
- Matthew J. Strickland - National Center on Birth Defects and Developmental DisabilitiesTiffany J. Riehle-Colarusso - US Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USAJeffrey P. Jacobs - College Station Medical CenterMark D. Reller - University of PortlandWilliam T. MahleLorenzo D. Botto - University of UtahPaige E. Tolbert - Emory UniversityMarshall L. Jacobs - Drexel UniversityFrancois G. Lacour-Gayet - University of Colorado DenverChristo I. Tchervenkov - McGill UniversityConstantine Mavroudis - Northwestern UniversityAdolfo Correa - US Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA
- Publication Details
- Cardiology in the young, v 18(S2), pp 92-100
- Publisher
- Cambridge Univ Press
- Number of pages
- 9
- Grant note
- The Children's Heart Foundation R01ES012967 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000266381300006
- Scopus ID
- 2-s2.0-60849091227
- Other Identifier
- 991021901514004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Pediatrics