Journal article
The incidence of venous thromboembolic events in trauma patients after tranexamic acid administration: an EAST multicenter study
Blood coagulation & fibrinolysis, Vol.32(1), pp.37-43
01 Jan 2021
PMID: 33196508
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To determine if there is a significant association between administration of tranexamic acid (TXA) in severely bleeding, injured patients, and venous thromboembolism (VTE), myocardial infarction (MI), or cerebrovascular accident (CVA). A multicenter, retrospective study was performed. Inclusion criteria were: age 18-80 years old and need for 5 units or more of blood in the first 24 h after injury. Exclusion criteria included: death within 24 h, pregnancy, administration of TXA more than 3 h following injury, and routine ultrasound surveillance for deep venous thrombosis. Incidence of VTE was the primary outcome. Secondary outcomes included MI, CVA, and death. A power analysis found that a total of 830 patients were needed to detect a true difference in VTE risk. 1333 patients (TXA = 887, No-TXA = 446 patients) from 17 centers were enrolled. There were no differences in age, shock index, Glasgow coma score, pelvis/extremity abbreviated injury score, or paralysis. Injury severity score was higher in the No-TXA group. Incidence of VTE, MI, or CVA was similar between the groups. The TXA group required significantly less transfusion (P < 0.001 for all products) and had a lower mortality [adjusted odds ratio 0.67 (95% confidence interval 0.45-0.98)]. Despite having a higher extremity/pelvis abbreviated injury score, results did not change when evaluating only patients with blunt injury. Use of TXA in bleeding, injured patients is not associated with VTE, MI, or CVA but is associated with a lower transfusion need and mortality.
Metrics
1 Record Views
Details
- Title
- The incidence of venous thromboembolic events in trauma patients after tranexamic acid administration: an EAST multicenter study
- Creators
- Lisbi Rivas - George Washington UniversityJordan Estroff - George Washington UniversityAndrew Sparks - George Washington UniversityJeffry Nahmias - University of California, IrvineRebecca Allen - George Washington UniversitySavannah R Smith - George Washington UniversityMatthew Kutcher - University of MississippiKristen Carter - University of California, IrvineAreg Grigorian - University of MississippiSpencer Albertson - University of MississippiDavid Turay - Loma Linda University Medical CenterJuan C Quispe - Loma Linda University Medical CenterXian Luo-Owen - Loma Linda University Medical CenterMichael Vella - University of PennsylvaniaJose Pascual - University of PennsylvaniaGabriella Tororello - University of PennsylvaniaMcKell Quattrone - University of KentuckyAndrew Bernard - University of KentuckyAshanthi Ratnasekera - Crozer-Keystone Health SystemAlice Lee - Crozer-Keystone Health SystemDanielle Tamburrini - Crozer-Keystone Health SystemCarlos Rodriguez - John Peter Smith HospitalKelly Harrell - John Peter Smith HospitalKokila Jeyamurugan - Tufts Medical CenterNikolay Bugaev - Tufts Medical CenterAnne Warner - Department of Surgery, Christiana Medical Center, Wilmington, DelawareJason Weinberger - Department of Surgery, Christiana Medical Center, Wilmington, DelawareJoshua P Hazelton - Department of Surgery, University Hospital, Camden, New JerseyMariam Selevany - Department of Surgery, University Hospital, Camden, New JerseyFranklin Wright - University of Colorado Anschutz Medical CampusAlexandra Kovar - University of Colorado Anschutz Medical CampusShane Urban - University of Colorado Anschutz Medical CampusAmy Hamrick - Spartanburg Regional Medical CenterMichael Mount - Spartanburg Regional Medical CenterMatthew Carrick - Plano Cancer InstituteDaniel C Cullinane - Marshfield ClinicGrace Chang - Sinai HospitalGary Jain - Sinai HospitalChance Spalding - Grant Medical CenterBabak Sarani - George Washington University
- Publication Details
- Blood coagulation & fibrinolysis, Vol.32(1), pp.37-43
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000661965500006
- Scopus ID
- 2-s2.0-85100070229
- Other Identifier
- 991022057017804721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology