Journal article
The influence of hemodynamics and wall biomechanics on the thrombogenicity of vein segments perfused in vitro 1
The Journal of surgical research, v 121(1), pp 31-37
2004
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study addresses the hypothesis that exposure to peripheral arterial (ART) or coronary (COR) hemodynamics and wall biomechanics affect platelet deposition on vein segments. Intact human saphenous vein (HSV) and porcine internal jugular vein (PIJV) segments were studied under venous (VEN), ART, and COR environments using
in vitro perfusion systems. Wall shear stress (τ) and circumferential wall stress (σ
θ) were calculated for PIJV segments. Platelet deposition was measured using a radioactive assay. PIJV ART segments exhibited a 14% increase in inner diameter over time (
P < 0.05). τ, acting on PIJV ART specimens, was less at 6 h compared with time 0 (
P < 0.05). σ
θ was lower in the VEN specimens compared with ART and COR groups (
P < 0.01). Platelet deposition decreased by 40% on PIJV ART segments (
P < 0.05) but increased 3.2-fold on PIJV COR segments (
P < 0.05)
versus VEN control segments. Platelet deposition was increased 1.75-fold in COR HSV cases
versus VEN segments. These data indicate that short-term exposure to COR conditions lead to enhanced platelet deposition, whereas ART conditions decrease platelet deposition.
Metrics
Details
- Title
- The influence of hemodynamics and wall biomechanics on the thrombogenicity of vein segments perfused in vitro 1
- Creators
- Donald A. Severyn - University of Pittsburgh Medical CenterSatish C. Muluk - University of Pittsburgh Medical CenterDavid A. Vorp - University of Pittsburgh Medical Center
- Publication Details
- The Journal of surgical research, v 121(1), pp 31-37
- Publisher
- Elsevier; SAN DIEGO
- Number of pages
- 7
- Grant note
- NHLBI NIH HHS: 1R01 HL 65745
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:000223437500006
- Scopus ID
- 2-s2.0-4143130285
- Other Identifier
- 991021944509004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Surgery