Journal article
The influence of radial RBC distribution, blood velocity profiles, and glycocalyx on coupled NO/O2 transport
Journal of applied physiology (1985), v 100(2), pp 482-492
Feb 2006
PMID: 16210436
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this investigation was to study the effect of the presence of red blood cells (RBCs) in the plasma layer near the arteriole wall on nitric oxide (NO) and oxygen (O2) transport. To this end, we extended a coupled NO and O2 diffusion-reaction model in the arteriole, developed by our group, to include the effect of the presence of RBCs in the plasma layer and the effect of convection. Two blood flow velocity profiles (plug and parabolic) were tested. The average hematocrit in the bloodstream was assumed to be constant in the central core and decreasing to zero in the boundary layer next to the endothelial surface layer. The effect of the presence or absence of RBCs near the endothelium was studied while varying the endothelial surface layer and boundary layer thickness. With RBCs present in the boundary layer, the model predicts that 1) NO decreases significantly in the endothelium and vascular wall; 2) there is a very small increase in endothelial and vascular wall Po2; 3) scavenging of NO by hemoglobin decreases with increasing thickness of the boundary layer; 4) the shape of the velocity profile influences both NO and Po2 gradients in the bloodstream; and 5) the presence of RBCs in the boundary layer near the endothelium has a much larger effect on NO than on O2 transport.
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Details
- Title
- The influence of radial RBC distribution, blood velocity profiles, and glycocalyx on coupled NO/O2 transport
- Creators
- Xuewen Chen - School of Biomedical Engineering, Science, and Health Systems, Drexel Univ., Philadelphia, PA 19104, USADov JaronKenneth A BarbeeDonald G Buerk
- Publication Details
- Journal of applied physiology (1985), v 100(2), pp 482-492
- Publisher
- American Physiological Society (APS); United States
- Grant note
- HL-068164 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:000235059300016
- Scopus ID
- 2-s2.0-33646348205
- Other Identifier
- 991014878269604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physiology
- Sport Sciences