Journal article
The innate immune response to hepatitis B virus infection: Implications for pathogenesis and therapy
Antiviral research, v 96(3), pp 405-413
Dec 2012
PMID: 23072881
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
► Hepatitis B virus (HBV) does not efficiently activate pattern recognition receptor (PRR)-mediated innate immune responses. ► HBV engages with multiple components of PRR signal transduction pathways. ► Activation of toll-like receptors (TLRs) and RIG-I-like receptors potently inhibits HBV replication. ► Interferons target multiple steps of the HBV life cycle. ► TLR7 agonists have demonstrated encouraging therapeutic efficacy in preclinical studies.
Pattern recognition receptor (PRR)-mediated innate immune responses play an essential role in defending the host from viral infections. Intriguingly, hepatitis B virus (HBV) has been shown to induce negligible innate immune responses during the early phase of infection. Whether this is due to the failure of the virus to activate PRRs or suppression of PRR signaling pathways by the virus remains controversial. However, a plethora of evidence suggests that HBV is sensitive to PRR ligand-induced antiviral responses. This review summarizes current understanding of the interaction between HBV and PRR-mediated host innate immunity, antiviral mechanisms of PRR responses against HBV and strategies to combat chronic HBV infection via induction of host innate antiviral responses.
Metrics
Details
- Title
- The innate immune response to hepatitis B virus infection: Implications for pathogenesis and therapy
- Creators
- Jinhong Chang - Drexel UniversityTimothy M. Block - Drexel UniversityJu-Tao Guo - Drexel University
- Publication Details
- Antiviral research, v 96(3), pp 405-413
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000312518100016
- Scopus ID
- 2-s2.0-84869118771
- Other Identifier
- 991019168779404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy
- Virology