Journal article
The integrated luteal progesterone: an assessment of luteal function
Fertility and sterility, v 48(6), pp 937-940
Dec 1987
PMID: 3678513
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An integrated luteal progesterone (ILPL) was calculated on the basis of a luteal progesterone (P) level with the assumption that the daily plasma P level in the luteal phase closely approximates a sine curve. The midluteal P-amplitude (K) was also obtained mathematically. Daily luteal P levels from five normal ovulatory cycles were assessed for the biologic variation of ILPL and K, then compiled to construct a normogram of the ILP during the luteal phase. The coefficient of variation of K and total ILPL in each cycle ranged from 9.7% to 24.3% and 3.5% to 13.2%, respectively. Fifty-two infertility patients were evaluated for their luteal function by the luteal P and estradiol (E2) level, K, ILPL , endometrial biopsy (EBX)-lag-day, as well as the lengths of follicular phase, luteal phase (L#), and cycle. Thirty-nine patients had EBX-lag day≤2 days and were designated as infertile-normal (INF-NL) luteal phase, while the remaining 13 patients who had EBX-lag day>2 days were considered as luteal phase defect (LPD). Significant (P<0.05) differences were observed between INF-NL and LPD in: luteal length (13.2±0.31 versus 11.0±0.58 days, respectively), and total ILPL (170±8.3 versus 113±8.5ng/ml-day, respectively). No differences were seen in luteal P, E2 and K levels, nor in follicular and cycle length. Significant (P<0.05) correlations were observed between total ILPL and luteal P, E2, L#, and K; while a negative correlation was noted between follicular and luteal length. Briefly, the total ILPL is a convenient and reliable parameter to assess luteal function in addition to or in place of EBX; and it can be used in clinical research or in monitoring therapy for ovulatory dysfunction.
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Details
- Title
- The integrated luteal progesterone: an assessment of luteal function
- Creators
- Chung H. Wu - Jefferson CollegeShahab S. Minassian - Jefferson College of Health Sciences
- Publication Details
- Fertility and sterility, v 48(6), pp 937-940
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program
- Web of Science ID
- WOS:A1987L243500008
- Scopus ID
- 2-s2.0-0023481790
- Other Identifier
- 991019184052304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Reproductive Biology