Journal article
The interaction of lithium and time-of-day on calcium, magnesium, parathyroid hormone, and calcitonin in rats
Psychiatry research, v 7(1), pp 121-131
1982
PMID: 6813887
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Effects of lithium on the concentrations and temporal patterns of serum and cerebellar calcium and magnesium, parathyroid hormone, and calcitonin were studied in 186 rats sacrificed around 24 hours of clock time. Serum calcium, serum and cerebellar magnesium, and parathyroid hormone were increased and calcitonin decreased in lithium-fed animals. Lithium-fed rats also showed different temporal patterns in serum calcium, parathyroid hormone, cerebellar magnesium, and calcitonin. Data support the hypothesis that lithium competes for calcium receptor sites, causing a compensatory increase in parathyroid hormone and decrease in calcitonin until a new, higher set-point for calcium is established. Lithium strongly affected biological rhythms, an effect which may account in part for the diverse literature on lithium's influence on calcium and magnesium regulation.
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Details
- Title
- The interaction of lithium and time-of-day on calcium, magnesium, parathyroid hormone, and calcitonin in rats
- Creators
- Donald L. McEachron - Donald L. McEachron, B.A., is at Department of Neurosciences, School of Medicine, USADaniel F. Kripke - Donald L. McEachron, B.A., is at Department of Neurosciences, School of Medicine, USAMaryruth Eaves - Donald L. McEachron, B.A., is at Department of Neurosciences, School of Medicine, USALinda Lenhard - Donald L. McEachron, B.A., is at Department of Neurosciences, School of Medicine, USADennis Pavlinac - Donald L. McEachron, B.A., is at Department of Neurosciences, School of Medicine, USALeonard Deftos - Donald L. McEachron, B.A., is at Department of Neurosciences, School of Medicine, USA
- Publication Details
- Psychiatry research, v 7(1), pp 121-131
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:A1982PE56600014
- Scopus ID
- 2-s2.0-0020369291
- Other Identifier
- 991019323677504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry