Journal article
The interaction of positive and negative sensory feedback loops in dynamic regulation of a motor pattern
Journal of computational neuroscience, v 27(2), pp 245-257
01 Oct 2009
PMID: 19291377
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In many rhythmic behaviors, phasic sensory feedback modifies the motor pattern. This modification is assumed to depend on feedback sign (positive vs. negative). While on a phenomenological level feedback sign is well defined, many sensory pathways also process antagonistic, and possibly contradictory, sensory information. We here model the locust flight pattern generator and proprioceptive feedback provided by the tegula wing receptor to test the functional significance of sensory pathways processing antagonistic information. We demonstrate that the tegula provides delayed positive feedback via interneuron 301, while all other pathways provide negative feedback. Contradictory to previous assumptions, the increase of wing beat frequency when the tegula is activated during flight is due to the positive feedback. By use of an abstract model we reveal that the regulation of motor pattern frequency by sensory feedback critically depends on the interaction of positive and negative feedback, and thus on the weighting of antagonistic pathways.
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Details
- Title
- The interaction of positive and negative sensory feedback loops in dynamic regulation of a motor pattern
- Creators
- Jessica Ausborn - Karolinska InstitutetHarald WolfWolfgang Stein
- Publication Details
- Journal of computational neuroscience, v 27(2), pp 245-257
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000269320300006
- Scopus ID
- 2-s2.0-69549108332
- Other Identifier
- 991020655668404721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Mathematical & Computational Biology
- Neurosciences