Journal article
The iron (Fe) and atherosclerosis study (FeAST): A pilot study of reduction of body iron stores in atherosclerotic peripheral vascular disease
The American heart journal, v 139(2), pp 337-345
01 Feb 2000
PMID: 10650308
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background Levels of body iron stores, represented by the serum ferritin concentration, rise with age after adolescence in men and menopause in women. This rise has been implicated mechanistically and epidemiologically in the pathogenesis of atherosclerosis through iron-induced oxygen free radical—mediated lipid oxidation. However, the precise contribution of iron stores to atherosclerosis and its complications are unknown because prospective randomized trials designed to test effects of reduction of iron stores on clinical outcomes in this disease have not been performed.
Methods and Results In preparation for a prospective randomized trial, a randomized pilot study was conducted to evaluate the feasibility, safety, and methodologic accuracy of calibrated reduction in iron stores by phlebotomy in a cohort of patients with advanced peripheral vascular disease. Phlebotomy resulted in a significant reduction in serum ferritin concentration to near targeted levels. Thus the formula for calculating the volume of blood to be removed to achieve a predetermined decrement in serum ferritin concentration was accurate and phlebotomy was not associated with any adverse laboratory or clinical effects.
Conclusions Reduction of body iron stores to a predetermined level is feasible and can be achieved in a timely manner with excellent patient compliance. Prospective randomized trials of calibrated reduction of body iron stores may be undertaken to define their pathophysiologic significance in atherosclerosis and other diseases in which excessive iron-induced oxidative stress has been implicated.
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Details
- Title
- The iron (Fe) and atherosclerosis study (FeAST): A pilot study of reduction of body iron stores in atherosclerotic peripheral vascular disease
- Creators
- Leo R Zacharski - Dartmouth CollegeBruce Chow - The Coordinating CenterPhilip W Lavori - Stanford UniversityPaula S Howes - White River Junction VA Medical CenterMarilyn R Bell - Department of Veterans Association Medical Centers, Pittsburgh, Pa, USAMichele A DiTommaso - Department of Veterans Association Medical Centers, Pittsburgh, Pa, USANina M Carnegie - Department of Veterans Association Medical Centers, Pittsburgh, Pa, USAFritz Bech - Dartmouth CollegeMorteza Amidi - University of PittsburghSatish Muluk - University of Pittsburgh
- Publication Details
- The American heart journal, v 139(2), pp 337-345
- Publisher
- Mosby, Inc
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:000085253300020
- Scopus ID
- 2-s2.0-0033952654
- Other Identifier
- 991021944605404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems