Journal article
The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration
The Journal of clinical investigation, v 104(3), pp 301-308
01 Aug 1999
PMID: 10430611
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Early-phase reactions (EPRs) and late-phase reactions (LPRs) are characteristic features of bronchial asthma, although the pathogenetic mechanisms responsible for each of the responses are not fully defined. A murine model of EPRs and LPRs was developed to investigate the role of IL-5 and eosinophils in development of both responses. After initial intraperitoneal sensitization and airway challenge to ovalbumin (OVA), mice were provoked by additional exposure to OVA. An EPR, characterized by a transient increase in airway responsiveness, was observed 5–30 minutes after antigen provocation. This response was followed by an LPR that reached its maximum at 6 hours after challenge and was characterized by increased airway responsiveness and significant lung eosinophilia. The EPR was blocked by cromoglycate and albuterol, whereas the LPR was abolished by cromoglycate and hydrocortisone. Before provocation with allergen, administration of anti–IL-5 antibody prevented the influx of eosinophils into the lung tissue and abolished the LPR but not EPR. These results suggest that IL-5 and eosinophils are essential for development of the LPR, but not EPR, in this model.
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Details
- Title
- The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration
- Creators
- Grzegorz Cieslewicz - Division of Basic Sciences, Department of Pediatrics, andAdrian Tomkinson - Division of Basic Sciences, Department of Pediatrics, andAndy Adler - Division of Basic Sciences, Department of Pediatrics, andCatherine Duez - Division of Basic Sciences, Department of Pediatrics, andJurgen Schwarze - Division of Basic Sciences, Department of Pediatrics, andKatsuyuki Takeda - Division of Basic Sciences, Department of Pediatrics, andKirsten A Larson - Division of Basic Sciences, Department of Pediatrics, andJames J Lee - Division of Basic Sciences, Department of Pediatrics, andCharles G Irvin - Division of Basic Sciences, Department of Pediatrics, andErwin W Gelfand - Division of Basic Sciences, Department of Pediatrics, and
- Publication Details
- The Journal of clinical investigation, v 104(3), pp 301-308
- Publisher
- American Society for Clinical Investigation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000083468500010
- Scopus ID
- 2-s2.0-0032699294
- Other Identifier
- 991014878427804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental