Journal article
The lithium test dose prediction method in aggressive children
Psychopharmacology bulletin, v 31(2), pp 379-382
01 Jan 1995
PMID: 7491395
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cooper and associates (1973) developed a method of ascertaining the lithium dosage required to attain a therapeutic serum level of 0.6 to 1.2 mEq/L. However, reports about the safety and accuracy of their method in children are limited (Geller & Fetner 1989). This study relates our experience with using this method in children. Subjects were 16 conduct-disordered children (13 males, 3 females), ages 8.97 to 17.14 years (mean, 12.73 +/- 2.12), who were treated with lithium to decrease aggressive behavior. Following a lithium 600-mg loading dose, a 24-hour serum lithium level was drawn from which a "predicted" lithium dosage was established. These dosages ranged from 600 to 1,800 mg/day (mean, 1,312.5 +/- 450) and the corresponding serum lithium levels at steady-state ranged from 0.58 to 1.13 mEq/L (mean, 0.87 +/- 0.15). No severe side effects were encountered. This suggests that the method is safe and useful for predicting lithium dosages in children.
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Details
- Title
- The lithium test dose prediction method in aggressive children
- Creators
- R P MaloneM A DelaneyJ F LuebbertM A WhiteK A BieseckerT B Cooper
- Publication Details
- Psychopharmacology bulletin, v 31(2), pp 379-382
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1995TF59500028
- Scopus ID
- 2-s2.0-0028802439
- Other Identifier
- 991019184215404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy
- Psychiatry