Journal article
The mechanism of the negative chronotropic and dromotropic actions of adenosine 5'-triphosphate in the heart: an update
Journal of cardiovascular pharmacology, v 56(1), pp 106-109
Jul 2010
PMID: 20386456
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Adenosine 5'-triphosphate (ATP) plays a critical role in intracellular metabolism and energetics. Extracellular ATP is rapidly degraded to adenosine by ectoenzymes. Both ATP and adenosine suppress cardiac pacemakers' automaticity and atrioventricular nodal conduction, albeit via the different mechanism of actions. This historical update summarizes the current knowledge regarding the negative chronotropic and dromotropic actions of ATP and discusses the clinical implications regarding the utility of ATP as a diagnostic and therapeutic agent in the management of neutrally mediated syncope and paroxysmal supra ventricular tachycardia.
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Details
- Title
- The mechanism of the negative chronotropic and dromotropic actions of adenosine 5'-triphosphate in the heart: an update
- Creators
- Amir Pelleg - Drexel UniversityBernard Belhassen
- Publication Details
- Journal of cardiovascular pharmacology, v 56(1), pp 106-109
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000280641400015
- Scopus ID
- 2-s2.0-77955227846
- Other Identifier
- 991019348910404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Pharmacology & Pharmacy