Journal article
The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp
Current opinion in microbiology, v 16(4), pp 452-458
Aug 2013
PMID: 23927894
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The apicoplast and the mitochondrion of Apicomplexa cooperate in providing essential metabolites. Their co-evolution during the ancestral acquisition of a plastid and subsequent loss of photosynthesis resulted in divergent metabolic pathways compared with mammals and plants. This is most evident in their chimerical haem synthesis pathway. Toxoplasma and Plasmodium mitochondria operate canonical tricarboxylic acid (TCA) cycles and electron transport chains, although the roles differ between Toxoplasma tachyzoites and Plasmodium erythrocytic stages. Glutamine catabolism provides TCA intermediates in both parasites. Isoprenoid precursor synthesis is the only essential role of the apicoplast in Plasmodium erythrocytic stages. An apicoplast-located fatty acid synthesis is dispensable in these stages, which instead predominantly salvage fatty acids, while in Plasmodium liver stages and in Toxoplasma tachyzoites fatty acid synthesis is an essential role of the plastid.
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Details
- Title
- The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp
- Creators
- Lilach Sheiner - Center for Tropical and Emerging Global Diseases & Department of Cellular Biology, University of Georgia, 500 D.W. Brooks Drive, Athens, GA 30602, USA. lilash@uga.eduAkhil B VaidyaGeoffrey I McFadden
- Publication Details
- Current opinion in microbiology, v 16(4), pp 452-458
- Publisher
- Elsevier; England
- Grant note
- R56 AI100569 / NIAID NIH HHS K99-AI103032 / NIAID NIH HHS R56-AI100569 / NIAID NIH HHS K99 AI103032 / NIAID NIH HHS R01 AI098413 / NIAID NIH HHS R01 AI028398 / NIAID NIH HHS R01-AI028398 / NIAID NIH HHS R01-AI098413 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000324356100014
- Scopus ID
- 2-s2.0-84890475029
- Other Identifier
- 991014877661704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Microbiology