The muscle quality index and mortality among males and females

Justin C. Brown; Michael O. Harhay; Meera N. Harhay

doi:10.1016/j.annepidem.2016.07.006

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The muscle quality index and mortality among males and females

Journal article

Open access

Peer reviewed

The muscle quality index and mortality among males and females

Justin C. Brown, Michael O. Harhay and Meera N. Harhay

Annals of epidemiology, v 26(9), pp 648-653

Sep 2016

DOI: https://doi.org/10.1016/j.annepidem.2016.07.006

PMID: 27480478

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Abstract

Aging

Mobility

Muscle strength

Physical activity

Physical function

The muscle quality index (MQI) was proposed as a measure to quantify age-related alterations in muscle function. It is unknown if the MQI predicts mortality. This was a population-based cohort study from the Third National Health and Nutrition Survey (NHANES III; 1988–1994). The MQI was quantified using a timed sit-to-stand test, body mass, and leg length. Vital status was obtained through the National Center for Health Statistics. We fit multivariable-adjusted regression models to estimate the hazard ratio (HR) and 95% confidence interval (CI) between the MQI and mortality. During 14.6 years of follow-up, 3299 (73.1%) of 4510 study participants died. Lower MQI was associated with a higher risk of mortality (Ptrend <.001). The multivariable-adjusted HR for mortality was 1.50 (95% CI, 1.15–1.96) for those in the lowest quintile of MQI compared to the highest quintile. The association between MQI and mortality was stronger among males (highest vs. lowest quintile of MQI, HR = 1.37 [95% CI, 1.00–1.87]; Ptrend = .001) compared to females (highest vs. lowest quintile of MQI, HR = 1.27 (95% CI, 0.89–1.83); Ptrend = .044; Pinteraction = .005]. The MQI predicts mortality and may differ between males and females. Additional research examining the MQI is warranted.

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Details

Title: The muscle quality index and mortality among males and females
Creators: Justin C. Brown - University of Pennsylvania
Michael O. Harhay - University of Pennsylvania
Meera N. Harhay - Drexel University
Publication Details: Annals of epidemiology, v 26(9), pp 648-653
Publisher: Elsevier
Resource Type: Journal article
Language: English
Academic Unit: College of Medicine
Web of Science ID: WOS:000384628800008
Scopus ID: 2-s2.0-84991643963
Other Identifier: 991019335324904721