Journal article
The nature of innate and adaptive interleukin-17A responses in sham or bacterial inoculation
Immunology, v 136(3), pp 325-333
01 Jul 2012
PMID: 22384827
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Streptococcus pyogenes is the causative agent of numerous diseases ranging from benign infections (pharyngitis and impetigo) to severe infections associated with high mortality (necrotizing fasciitis and bacterial sepsis). As with other bacterial infections, there is considerable interest in characterizing the contribution of interleukin-17A (IL-17A) responses to protective immunity. We here show significant il17a up-regulation by quantitative real-time PCR in secondary lymphoid organs, correlating with increased protein levels in the serum within a short time of S. pyogenes infection. However, our data offer an important caveat to studies of IL-17A responsiveness following antigen inoculation, because enhanced levels of IL-17A were also detected in the serum of sham-infected mice, indicating that inoculation trauma alone can stimulate the production of this cytokine. This highlights the potency and speed of innate IL-17A immune responses after inoculation and the importance of proper and appropriate controls in comparative analysis of immune responses observed during microbial infection.
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Details
- Title
- The nature of innate and adaptive interleukin-17A responses in sham or bacterial inoculation
- Creators
- Deborah L. W. Chong - Queen's University BelfastRebecca J. Ingram - Queen's University BelfastDaniel E. Lowther - Hammersmith HospitalRoshell Muir - Queen's University BelfastShiranee Sriskandan - Hammersmith HospitalDaniel M. Altmann - Hammersmith Hospital
- Publication Details
- Immunology, v 136(3), pp 325-333
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- G0700153 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission G0700153 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000304765100007
- Scopus ID
- 2-s2.0-84861755491
- Other Identifier
- 991021944017204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology