Journal article
The neurobiology of aging
Epilepsy research, v 68(1)
2006
PMID: 16386406
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Basic principles of the neurobiology of aging were reviewed within selected topic areas chosen for their potential relevance to epileptogenesis in the aging brain. The availability of National Institute on Aging-supported aged mouse and rat strains and other biological resources for studies of aging and age-associated diseases was presented, and general principles of animal use in gerontological research were discussed. Neurobiological changes during normal brain aging were compared and contrasted with neuropathological events of Alzheimer's disease (AD) and age-associated memory impairment (AAMI). Major themes addressed were the loss of synaptic connections as vulnerable neurons die and circuits deteriorate in AD, the absence of significant neuron loss but potential synaptic alteration in the same circuits in AAMI, and the effects of decreased estrogen on normal aging. The “calcium hypothesis of brain aging” was examined by a review of calcium dyshomeostasis and synaptic communication in aged hippocampus, with particular emphasis on the role of L-type voltage-gated calcium channels during normal aging. Established and potential mechanisms of hippocampal plasticity during aging were discussed, including long-term potentiation, changes in functional connectivity, and increased gap junctions, the latter possibly being related to enhanced network excitability. Lastly, application of microarray gene chip technology to aging brain studies was presented and use of the hippocampal “zipper slice” preparation to study aged neurons was described.
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Details
- Title
- The neurobiology of aging
- Creators
- K.M. Kelly - Department of Neurology, Drexel University College of Medicine, Allegheny General Hospital, 940 S. Tower, 320 E. North Ave, Pittsburgh, PA 15212, USAN.L. Nadon - Office of Biological Resources, National Institute of Aging, Bethesda, MD, USAJ.H. Morrison - Neurobiology of Aging Laboratories, Mount Sinai Medical Center, New York, NY, USAO. Thibault - University of KentuckyC.A. Barnes - University of ArizonaE.M. Blalock - University of Kentucky
- Publication Details
- Epilepsy research, v 68(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000235984000002
- Scopus ID
- 2-s2.0-31344471721
- Other Identifier
- 991019168969704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology