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Accepted (AM)Open Access (License Unspecified), Open
Journal article
The neuroinflammatory component of negative affect in patients with chronic pain
Molecular psychiatry, v 26(3), pp 864-874
01 Mar 2021
PMID: 31138890
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patients is linked to elevations in the brain levels of the glial marker 18 kDa translocator protein (TSPO), and changes in functional connectivity. 25 cLBP patients (42.4 ± 13 years old; 13F, 12M) with chronic low back pain (cLBP) and 27 healthy control subjects (48.9 ± 13 years old; 14F, 13M) received an integrated (i.e., simultaneous) positron emission tomography (PET)/magnetic resonance imaging (MRI) brain scan with the second-generation TSPO ligand [
C]PBR28. The relationship between [
C]PBR28 signal and NA was assessed first with regression analyses against Beck Depression Inventory (BDI) scores in patients, and then by comparing cLBP patients with little-to-no, or mild-to-moderate depression against healthy controls. Further, the relationship between PET signal, BDI and frontolimbic functional connectivity was evaluated in patients with mediation models. PET signal was positively associated with BDI scores in patients, and significantly elevated in patients with mild-to-moderate (but not low) depression compared with controls, in anterior middle and pregenual anterior cingulate cortices (aMCC, pgACC). In the pgACC, PET signal was also associated with this region's functional connectivity to the dorsolateral PFC (pgACC-dlPFC), and mediated of the association between pgACC-dlPFC connectivity and BDI. These observations support a role for glial activation in pain-comorbid NA, identifying in neuroinflammation a potential therapeutic target for this condition.
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Details
- Title
- The neuroinflammatory component of negative affect in patients with chronic pain
- Creators
- D S Albrecht - Athinoula A. Martinos Center for Biomedical ImagingM Kim - Athinoula A. Martinos Center for Biomedical ImagingO Akeju - Boston UniversityA Torrado-Carvajal - Harvard Medical SchoolR R Edwards - Brigham and Women's HospitalY Zhang - Boston UniversityC Bergan - Athinoula A. Martinos Center for Biomedical ImagingE Protsenko - Athinoula A. Martinos Center for Biomedical ImagingA Kucyi - Stanford UniversityA D Wasan - University of PittsburghJ M Hooker - Athinoula A. Martinos Center for Biomedical ImagingV Napadow - Athinoula A. Martinos Center for Biomedical ImagingM L Loggia - Athinoula A. Martinos Center for Biomedical Imaging
- Publication Details
- Molecular psychiatry, v 26(3), pp 864-874
- Publisher
- Springer Nature
- Grant note
- S10 OD023517 / NIH HHS R21 NS087472 / NINDS NIH HHS P41 EB015896 / NIBIB NIH HHS R01 NS094306 / NINDS NIH HHS P41 RR014075 / NCRR NIH HHS R01 NS095937 / NINDS NIH HHS T32 EB013180 / NIBIB NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000622346900013
- Scopus ID
- 2-s2.0-85079629912
- Other Identifier
- 991021463540204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences
- Psychiatry