Journal article
The nitric oxide synthesis inhibitor L-name facilitates associative learning
Progress in neuro-psychopharmacology & biological psychiatry, v 20(7), pp 1183-1195
1996
PMID: 8938819
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
1.
1. Nitric oxide has been suggested to play an important role in synaptic plasticity and in learning.
2.
2. The authors (examined the effects of N
w
-nitro-L-arginine methyl ester, a competitive and enantiomeric specific inhibitor of nitric oxide synthase, on classical conditioning of the rabbit's nictitating membrane response.
3.
3. It was found that L-NAME significantly enhanced the acquisition of conditioned responses.
4.
4. The enhanced conditioned responses were not due to a sensitization of the conditioned and unconditioned reflexes or to changes in baseline levels of responding.
5.
5. The dose and route of administration of L-NAME employed in this study had no effect on blood pressure.
6.
6. These results suggest that nitric oxide normally functions as a tonic inhibitory modulator of associative learning and that procedures aimed at decreasing its production may provide a novel approach for improving learning.
Metrics
Details
- Title
- The nitric oxide synthesis inhibitor L-name facilitates associative learning
- Creators
- Wei Du - Drexel UniversityJohn A. Harvey - Drexel University
- Publication Details
- Progress in neuro-psychopharmacology & biological psychiatry, v 20(7), pp 1183-1195
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:A1996VQ01400007
- Scopus ID
- 2-s2.0-0030273481
- Other Identifier
- 991019167562604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry