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The nurse practitioner's role in managing dyslipidemia and other cardiovascular risk factors in HIV-infected patients: impact of antiretroviral therapy
Journal article

The nurse practitioner's role in managing dyslipidemia and other cardiovascular risk factors in HIV-infected patients: impact of antiretroviral therapy

Suzanne Willard
The Journal of the Association of Nurses in AIDS Care, v 17(1)
Jan 2006
PMID: 16686080

Abstract

Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Cardiovascular Diseases - prevention & control Drug Interactions Dyslipidemias - chemically induced Dyslipidemias - nursing Dyslipidemias - prevention & control HIV Infections - drug therapy HIV Infections - metabolism HIV Infections - nursing Humans Nurse Practitioners Practice Guidelines as Topic
The beneficial effects of antiretroviral therapy (ART) for the treatment of HIV disease have been accompanied by metabolic changes associated with an increased risk of cardiovascular disease. These changes, which include dyslipidemia, change in body fat distribution, and insulin resistance, resemble the symptoms of metabolic syndrome. Protease inhibitors, nucleoside analogue reverse transcriptase inhibitors, and nonnucleoside reverse transcriptase inhibitors have all been associated with dyslipidemia to varying degrees. In addition, patients on ART show an increased risk of myocardial infarction and other cardiovascular events. According to the recommendations of the National Cholesterol Education Program and the Adult AIDS Clinical Trial Group, health care providers should assess cardiovascular risk before starting ART and then continue to monitor lipid levels. Treatment of ART-associated dyslipidemia should follow the following sequence: therapeutic lifestyle changes, lipid-lowering drug therapy, and finally, modifying ART if necessary. By providing education, support, and follow-up care, nurse practitioners can help to implement these steps.

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Web of Science research areas
Nursing
Public, Environmental & Occupational Health
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