Journal article
The path to metastatic mouse models of colorectal cancer
Oncogene, v 37(19), pp 2481-2489
01 May 2018
PMID: 29463860
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The study and comprehension of the molecular mechanisms underlying cancer biology strongly rely on mouse modeling. An ideal mouse model should have molecular, histopathological, and etiological characteristics as close as possible to those of the corresponding human tumors. Among solid tumors, colorectal cancer (CRC) is one of the malignancies that best suits reproduction in an animal model: it evolves through a progressive set of molecular events and is generally associated with a precise histopathology and a neat cataloging of stages and grades. The development of refined CRC mouse models over several decades has seen them recently evolve toward sophisticated systems that ever more closely approximate the human pathology, with different models addressing different human CRC subtypes. In particular, a metastatic CRC model has been seen as a "holy grail" in this field, and we describe in this review the path taken to achieve metastatic models and discuss the path forward.
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Details
- Title
- The path to metastatic mouse models of colorectal cancer
- Creators
- Gabriele Romano - Drexel University, Pharmacology and PhysiologySharmeen Chagani - The University of Texas MD Anderson Cancer CenterLawrence N. Kwong - The University of Texas MD Anderson Cancer Center
- Publication Details
- Oncogene, v 37(19), pp 2481-2489
- Publisher
- Springer Nature
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000431873400002
- Scopus ID
- 2-s2.0-85042223149
- Other Identifier
- 991021965770304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Genetics & Heredity
- Oncology