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The phosphocreatine overshoot occurs independent of myocardial work
Journal article   Peer reviewed

The phosphocreatine overshoot occurs independent of myocardial work

L J Kaplan, C F Bellows, S Carter, H Blum and G J Whitman
Biochimie, v 77(4)
1995
PMID: 8589052

Abstract

Adenosine Triphosphate - analysis Adenosine Triphosphate - physiology Animals Energy Metabolism Heart - physiology In Vitro Techniques Male Myocardial Reperfusion Myocardium - chemistry Myocardium - metabolism Oxygen Consumption Phosphocreatine - chemistry Phosphocreatine - physiology Pressure Rats Rats, Sprague-Dawley
Although the exact mechanism(s) responsible for the phosphocreatine/ATP overshoot have not been completely elucidated, our data demonstrate that the overshoot does not stem from reduced myocardial work, and consequently, reduced utilization of phosphocreatine (PCr). Additionally, we highlight a basic difference in the physiologic responses of skeletal and cardial muscle to work demands. By understanding the bioenergetic derangements which accompany reperfusion injury, one may hope to better salvage post-ischemic myocardium.

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Web of Science research areas
Biochemistry & Molecular Biology
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