Journal article
The polymerization of sickle hemoglobin in solutions and cells
Experientia, v 49(2)
15 Feb 1993
PMID: 8440349
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The polymerization of sickle hemoglobin occurs by the same mechanisms in solutions and in cells, and involves the formation of 14 stranded fibers from hemoglobin molecules which have assumed a deoxy quaternary structure. The fibers form via two types of highly concentration-dependent nucleation processes: homogeneous nucleation in solutions with hemoglobin activity above a critical activity, and heterogeneous nucleation in similarly supersaturated solutions which also contain hemoglobin polymers. The latter pathway is dominant, and creates polymer arrays called domains. The individual polymers bend, but also cross-link, and the resulting mass behaves as a solid. The concentration of polymerized hemoglobin increases exponentially unless clamped by rate limiting effects such as oxygen delivery.
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Details
- Title
- The polymerization of sickle hemoglobin in solutions and cells
- Creators
- F A Ferrone - Department of Physics and Atmospheric Science, Drexel University, Philadelphia, Pennsylvania 19104
- Publication Details
- Experientia, v 49(2)
- Publisher
- Springer Nature; Switzerland
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:A1993KP39600008
- Scopus ID
- 2-s2.0-0027398484
- Other Identifier
- 991014878584704721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology