Journal article
The postnatal maternal environment affects autoimmune disease susceptibility in A/J mice
Cellular immunology, v 260(2), pp 119-127
2010
PMID: 19914609
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The postnatal maternal environment is known to increase susceptibility to a number of autoimmune diseases. Here we asked whether the postnatal maternal environment could influence autoimmune disease development to day 3 thymectomy (d3tx)-induced autoimmune ovarian disease (AOD) and experimental allergic encephalomyelitis (EAE) in cross-fostered A/J and B6 mice. A/J pups foster-nursed by B6 mothers exhibit an increase in autoimmune disease development while cross-fostering B6 pups on A/J mothers did not alter their susceptibility. The increase in AOD incidence seen in foster-nursed d3tx A/J mice correlated with a decrease in the total number of CD4
+ T cells in the lymph nodes of these animals. Analysis of the cellular composition in the milk revealed that B6 mice shed significantly more maternally derived lymphocytes into their milk compared to A/J mothers. These data suggest that there are maternally derived postnatal factors that influence the development of autoimmune disease in A/J mice.
Metrics
Details
- Title
- The postnatal maternal environment affects autoimmune disease susceptibility in A/J mice
- Creators
- Laure K Case - Department of Medicine, University of Vermont, Burlington, VT 05405, USARoxana del Rio - Department of Medicine, University of Vermont, Burlington, VT 05405, USAElizabeth A Bonney - Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Vermont, Burlington, VT 05405, USAJames F Zachary - Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USAElizabeth P Blankenhorn - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USAKenneth S.K Tung - Departments of Pathology and Microbiology, University of Virginia, Charlottesville, VA 22908, USACory Teuscher - Department of Medicine, University of Vermont, Burlington, VT 05405, USA
- Publication Details
- Cellular immunology, v 260(2), pp 119-127
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000273594200010
- Scopus ID
- 2-s2.0-71349084063
- Other Identifier
- 991014877776704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Immunology