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Journal article
The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients
Lupus, v 26(10), pp 1051-1059
01 Sep 2017
PMID: 28420054
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Autoantibodies to dense fine speckles 70 (DFS70) are purported to rule out the diagnosis of SLE when they occur in the absence of other SLE-related autoantibodies. This study is the first to report the prevalence of anti-DFS70 in an early, multinational inception SLE cohort and examine demographic, clinical, and autoantibody associations. Patients were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis. The association between anti-DFS70 and multiple parameters in 1137 patients was assessed using univariate and multivariate logistic regression. The frequency of anti-DFS70 was 7.1% (95% CI: 5.7-8.8%), while only 1.1% (95% CI: 0.6-1.9%) were monospecific for anti-DFS70. In multivariate analysis, patients with musculoskeletal activity (Odds Ratio (OR) 1.24 [95% CI: 1.10, 1.41]) or with anti-β2 glycoprotein 1 (OR 2.17 [95% CI: 1.22, 3.87]) were more likely and patients with anti-dsDNA (OR 0.53 [95% CI: 0.31, 0.92]) or anti-SSB/La (OR 0.25 [95% CI: 0.08, 0.81]) were less likely to have anti-DFS70. In this study, the prevalence of anti-DFS70 was higher than the range previously published for adult SLE (7.1 versus 0-2.8%) and was associated with musculoskeletal activity and anti-β2 glycoprotein 1 autoantibodies. However, 'monospecific' anti-DFS70 autoantibodies were rare (1.1%) and therefore may be helpful to discriminate between ANA-positive healthy individuals and SLE.
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Details
- Title
- The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients
- Creators
- M Y Choi - University of CalgaryA E Clarke - University of CalgaryY St Pierre - McGill University Health CentreJ G Hanly - Dalhousie UniversityM B Urowitz - University of TorontoJ Romero-Diaz - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránC Gordon - University of BirminghamS-C Bae - Hanyang University Seoul HospitalS Bernatsky - McGill University Health CentreD J Wallace - Cedars-Sinai Medical CenterJ T Merrill - Oklahoma Medical Research FoundationD A Isenberg - University College LondonA Rahman - University College LondonE M Ginzler - SUNY Downstate Health Sciences UniversityM Petri - Johns Hopkins MedicineI N Bruce - Manchester Academic Health Science CentreM A Dooley - University of North Carolina at Chapel HillP Fortin - Centre hospitalier universitaire de QuébecD D Gladman - Toronto Western HospitalJ Sanchez-Guerrero - Mount Sinai HospitalK Steinsson - Reykjavík UniversityR Ramsey-Goldman - Northwestern UniversityM A Khamashta - St Thomas' HospitalC Aranow - Feinstein Institute for Medical ResearchG S Alarcón - University of Alabama at BirminghamS Manzi - Allegheny Health NetworkO Nived - Lund UniversityA A Zoma - Hairmyres HospitalR F van Vollenhoven - Karolinska InstitutetM Ramos-Casals - Consorci Institut D'Investigacions Biomediques August Pi I SunyerG Ruiz-Irastorza - BioCruces Health research InstituteS S Lim - Emory UniversityK C Kalunian - University of California, San DiegoM Inanc - Istanbul UniversityD L Kamen - Medical University of South CarolinaC A Peschken - University of ManitobaS Jacobsen - Copenhagen University HospitalA Askanase - New York University Langone Orthopedic HospitalJ Buyon - 36 New York School of Medicine, New York, USM Mahler - Nova MedicalM J Fritzler - University of Calgary
- Publication Details
- Lupus, v 26(10), pp 1051-1059
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000407822000005
- Scopus ID
- 2-s2.0-85025451913
- Other Identifier
- 991021934002404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology