Journal article
The rabbit as a model for studies of cocaine exposure in utero
Laboratory animal science (Chicago), v 45(2)
Apr 1995
PMID: 7603017
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The rabbit has been used to model the potential effects of in utero exposure to cocaine on fetal and postnatal development. Special advantages of this animal model include the fact that cocaine can be easily administered intravenously, thus mimicking crack cocaine use by pregnant women. Results indicate that at the dosage used (8 mg/kg of body weight, given intravenously daily) gross teratologic defects do not develop. Cocaine-exposed pregnant does not differ from controls in weight gain or in the number of live kits delivered. Cocaine-exposed kits do not differ from controls in survival or in postnatal weight gain. The importance of this rabbit model is that offspring that have been exposed to these doses of cocaine in utero have a variety of abnormalities in structure and function of the central nervous system in the absence of any major teratologic defects.
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Details
- Title
- The rabbit as a model for studies of cocaine exposure in utero
- Creators
- E H Murphy - Department of Anatomy and Neurobiology, Medical College of Pennsylvania, Philadelphia 19129, USAJ G HammerM D SchumannM Y GroceX H WangL JonesA G RomanoJ A Harvey
- Publication Details
- Laboratory animal science (Chicago), v 45(2)
- Publisher
- United States
- Grant note
- P01DA06871 / NIDA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Neurobiology and Anatomy
- Web of Science ID
- WOS:A1995QU96200007
- Scopus ID
- 2-s2.0-0028920196
- Other Identifier
- 991014877804804721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Veterinary Sciences
- Zoology