Journal article
The radiation therapy of early stage cutaneous T-cell lymphoma
International journal of radiation oncology, biology, physics, v 18(6), pp 1333-1339
1990
PMID: 1695214
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Results of different radiotherapy schedules used for early stage (T1-2, N0-1, M0) cutaneous T-cell lymphoma (CTCL) are compared in a series of 45 patients (22 patients treated with high dose total skin electron beam therapy (TSEB) with curative intent, 18 patients treated with palliative radiotherapy, and 5 patients treated with high dose local electron beam). At 3, 5, and 10 years after diagnosis the high dose TSEB treatment group had a probability of overall survival of 91%, 86%, and 75%, respectively, compared with 94%, 88%, and 88% for the palliative treatment group. The complete response (CR) rate for the high dose TSEB treatment group was 82% (
18
22
), compared with a 57% (
4
7
) complete response rate for seven patients in the palliative group who received low dose TSEB (<25 Gy in 6–7 weeks) followed by daily application of topical mechlorethamine hydrochloride (HN2). However, the probability of continued remission at 3, 5, and 10 years was 44%, 44%, and 33%, respectively, for the high dose TSEB group and 25%, 25%, and 0%, respectively, for the low dose TSEB + HN2 group. The median disease-free survival was 17.5 months for the high dose TSEB group versus 5.5 months for the low dose TSEB + HN2 group. The five patients who were treated with high doses of local electrons to a single local field had an overall survival rate of 80%, a median survival rate of 64 months, and a median length of continued remission of 31 months. These results indicate that high-dose electron beam can result in long-term disease-free survival in patients with localized and limited extent skin involvement with cutaneous T-cell lymphoma.
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Details
- Title
- The radiation therapy of early stage cutaneous T-cell lymphoma
- Creators
- Bizhan Micaily - Hahnemann University HospitalCharles Moser - Hahnemann University HospitalEric C Vonderheid - Temple UniversityChristopher Koprowski - Hahnemann University HospitalDavid Lightfoot - Hahnemann University HospitalArnold Markoe - Hahnemann University HospitalLuther Brady - Hahnemann University Hospital
- Publication Details
- International journal of radiation oncology, biology, physics, v 18(6), pp 1333-1339
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:A1990DQ11400009
- Scopus ID
- 2-s2.0-0025363476
- Other Identifier
- 991019183930304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging