Journal article
The rationale for immunosuppressive therapy for HIV infection
Current opinion in HIV & AIDS, v 2(3), pp 207-212
May 2007
PMID: 19372888
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This article reviews the characteristics of HIV-associated immune activation, describes its prognostic significance and highlights the lack of knowledge of the mechanism by which HIV-1 infection induces this phenomenon.
A recent cohort analysis found that the level of HIV-1 RNA in plasma has only minimal predictive value for the rate of decline of the CD4+ T-lymphocyte count in an individual patient infected with HIV-1. This suggests that factors in addition to viral replication must play an important role in the genesis of immune deficiency in HIV-1 infection, and has rekindled interest in the generalized T-cell activation induced by HIV-1 infection and the apoptosis that results as the likely culprit.
Measures of T-cell activation provide independent and, in some studies, more powerful, prognostic information as to the course of HIV-1 disease compared with the viral load. The case is made for focused studies of immune suppression carefully designed to decipher the mechanism(s) involved in HIV-associated immune activation and to develop unique therapies aimed at treating the pathogenic consequences of HIV-1 infection. Given its prognostic significance, the reduction of immune activation is an important goal of the therapy of HIV-1 infection.
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Details
- Title
- The rationale for immunosuppressive therapy for HIV infection
- Creators
- Jeffrey M Jacobson - Drexel University
- Publication Details
- Current opinion in HIV & AIDS, v 2(3), pp 207-212
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000208417800007
- Scopus ID
- 2-s2.0-34250679775
- Other Identifier
- 991019335513904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases