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Accepted (AM)Open Access (License Unspecified), Open
Journal article
The relationship between multiple myeloma and occupational exposure to six chlorinated solvents
Occupational and environmental medicine (London, England), v 68(6), pp 391-399
Jun 2011
PMID: 20833760
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ObjectivesFew studies have examined whether exposure to chlorinated solvents is associated with multiple myeloma. We evaluated associations between multiple myeloma and occupational exposure to six chlorinated solvents: 1,1,1-trichloroethane, trichloroethylene (TCE), methylene chloride (DCM), perchloroethylene, carbon tetrachloride and chloroform.Methods In-person interviews obtained occupational histories and information on jobs with likely solvent exposure. We assigned exposure metrics of probability, frequency, intensity and confidence using job-exposure matrices modified by job-specific questionnaire information. We used logistic regression to estimate ORs and 95% CIs for associations between multiple myeloma and ever exposure to each, and any, chlorinated solvent and analysed whether associations varied by duration and cumulative exposure. We also considered all occupations that were given the lowest confidence scores as unexposed and repeated all analyses.ResultsRisk of multiple myeloma was elevated for subjects ever exposed to 1,1,1-trichloroethane (OR (95% CI): 1.8 (1.1 to 2.9)). Ever exposure to TCE or DCM also entailed elevated, but not statistically significant, risks of multiple myeloma; these became statistically significant when occupations with low confidence scores were considered unexposed (TCE: 1.7 (1.0 to 2.7); DCM: 2.0 (1.2 to 3.2)). Increasing cumulative exposure to perchloroethylene was also associated with increasing multiple myeloma risk. We observed non-significantly increased multiple myeloma risks with exposure to chloroform; however, few subjects were exposed.ConclusionsEvidence from this relatively large case-control study suggests that exposures to certain chlorinated solvents may be associated with increased incidence of multiple myeloma; however, the study is limited by relatively low participation (52%) among controls.
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Details
- Title
- The relationship between multiple myeloma and occupational exposure to six chlorinated solvents
- Creators
- Laura S Gold - Fred Hutch Cancer CenterPatricia A Stewart - Product Innovation and Engineering (United States) (United States, Saint James) - LLCKevin Milliken - University of WashingtonMark Purdue - National Institutes of HealthRichard Severson - Wayne State UniversityNoah Seixas - University of WashingtonAaron Blair - National Institutes of HealthPatricia Hartge - National Institutes of HealthScott Davis - University of WashingtonAnneclaire J De Roos - University of Washington
- Publication Details
- Occupational and environmental medicine (London, England), v 68(6), pp 391-399
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000290516600004
- Scopus ID
- 2-s2.0-79955961294
- Other Identifier
- 991020099868904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health