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Journal article
The release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: A possible link between cytokine production and sympathetic transmission
Mechanisms of ageing and development, v 129(12), pp 728-734
2008
PMID: 18973771
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aging results in a general decline in the response to external insults, including acute inflammatory challenges. In young animals, the inflammatory response requires activation of the sympathetic system, including neurotransmitters such as ATP, and catecholamines (epinephrine and norepinephrine). To test whether aging affects activation of this axis, and whether this in turn might affect cytokine release, we administered lipopolysaccharide (LPS) i.p. to adult, middle-aged and aged Fisher 344 rats (6-, 15- and 23-month old, respectively) and evaluated the early (0–12
h) serum levels of Neuropeptide-Y (NP-Y), ATP and vanillyl mandelic acid (VMA, as an indirect measurement of catecholamine levels). In addition, we evaluated the association between these factors and serum levels of the cytokines tumor necrosis factor-alpha (TNFα) and interleukin-10 (IL-10). Induction of both ATP and NP-Y was markedly reduced in the serum of aged animals, when compared to their younger counterparts, while induction of VMA was not affected by age. In spite of these changes, serum levels of TNFα and IL-10 were strongly hyper induced and delayed in aged rats. The results suggest that during aging there is a dysregulation in sympathetic neurotransmitter regulatory mechanisms, and this might play a role in the impairment of the inflammatory response.
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- Title
- The release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: A possible link between cytokine production and sympathetic transmission
- Creators
- Verónica Donoso - Pontificia Universidad Católica de ChileChristian R. Gomez - Diego Portales UniversityMiguel Ángel Orriantia - Pontificia Universidad Católica de ChileViviana Pérez - Cell and Structural Biology, Barshop Institute for Longevity and Aging Studies, University Health Science Center at San Antonio, San Antonio, TX 78229, USAClaudio Torres - Drexel UniversityClaudio Coddou - Pontificia Universidad Católica de ChilePablo Nelson - University of Santiago ChileKevin Maisey - University of Santiago ChileBernardo Morales - University of Santiago ChileRicardo Fernandez - Andrés Bello National UniversityMónica Imarai - University of Santiago ChileJuan Pablo Huidobro-Toro - Pontificia Universidad Católica de ChileFelipe Sierra - Lankenau Institute for Medical Research, Drexel University College of Medicine, Philadelphia, PA, USAClaudio Acuña-Castillo - University of Santiago Chile
- Publication Details
- Mechanisms of ageing and development, v 129(12), pp 728-734
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000262809200006
- Scopus ID
- 2-s2.0-57049171874
- Other Identifier
- 991019168203004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology