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Accepted (AM)Open Access (License Unspecified), Open
Journal article
The rhythm section: an update on spinal interneurons setting the beat for mammalian locomotion
Current opinion in physiology, v 8
01 Apr 2019
PMID: 31179403
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To initiate and support locomotion, rhythm generating neurons in the spinal central pattern generator convert descending input into a rhythmic signal which is conveyed to downstream neurons, leading to the recruitment of motor neurons and the activation of muscles. Although two genetically-defined neuronal populations have been linked to rhythm generation, a single all-inclusive rhythm generating population has yet to be identified. Here, we consolidate recent work aimed at identifying rhythm generating neurons, summarize the evidence for the involvement of two neuronal populations in rhythm generation, describe the challenges in identifying a marker for rhythm generating neurons, and discuss potential directions to take in integrating spinal rhythm generating neurons into recently identified speed-dependent locomotor circuits.
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Details
- Title
- The rhythm section: an update on spinal interneurons setting the beat for mammalian locomotion
- Creators
- Kimberly J. Dougherty - Drexel UniversityNgoc T. Ha - Drexel University
- Publication Details
- Current opinion in physiology, v 8
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- R01 NS095366; R01 NS104194 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01NS095366 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000471296600014
- Scopus ID
- 2-s2.0-85062041181
- Other Identifier
- 991019169665504721
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- Web of Science research areas
- Physiology