Journal article
The risks of statin use in pregnancy: A systematic review
Journal of clinical lipidology, v 10(5), pp 1081-1090
01 Oct 2016
PMID: 27678424
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Statins are contraindicated in pregnancy; however, as women delay pregnancy and statin use increases the risk of statin exposure in pregnancy is likely to rise. In contrast to some early reports that statins are teratogenic, more recent observational studies have called into question the teratogenic risk of statins. Therefore, whether statins are associated with congenital anomalies or other pregnancy complications remains an important clinical question. This article provides an up-to-date systematic review on the risks of statins in pregnancy. We conducted a literature search to identify relevant English language studies related to statin exposure and pregnancy. Single case reports, animal studies, studies only published in abstract form, and non-English language studies were excluded. A total of 16 clinical studies were included in this systematic review. Although early uncontrolled case series reported congenital anomalies associated with statin use, more recent observational studies did not report an increased risk of congenital anomalies with statin exposure in pregnancy when compared to control groups or the prevalence of congenital anomalies in the general population. Our findings show no clear relationship of congenital anomalies with statin use in pregnancy, and our study supports the findings that statins are probably not teratogenic. However, until more information is available, statins should still be avoided in pregnancy. (C) 2016 National Lipid Association. All rights reserved.
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Details
- Title
- The risks of statin use in pregnancy: A systematic review
- Creators
- Dean G. Karalis - University of PennsylvaniaAlethea N. Hill - University of South AlabamaShari Clifton - University of Oklahoma Health Sciences CenterRobert A. Wild - University of Oklahoma Health Sciences Center
- Publication Details
- Journal of clinical lipidology, v 10(5), pp 1081-1090
- Publisher
- Elsevier
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000385903700005
- Scopus ID
- 2-s2.0-84994311158
- Other Identifier
- 991019348979804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy