Journal article
The role of Phafin proteins in cell signaling pathways and diseases
Open life sciences, v 19(1), 20220896
01 Jan 2024
PMID: 38947768
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Membrane-associated proteins are important membrane readers that mediate and facilitate the signaling and trafficking pathways in eukaryotic membrane-bound compartments. The protein members in the Phafin family are membrane readers containing two phosphoinositide recognition domains: the Pleckstrin Homology domain and the FYVE (Fab1, YOTB, Vac1, and early endosome antigen 1) domain. Phafin proteins, categorized into two subfamilies, Phafin1 and Phafin2, associate with cellular membranes through interactions involving membrane-embedded phosphoinositides and phosphoinositide-binding domains. These membrane-associated Phafin proteins play pivotal roles by recruiting binding partners and forming complexes, which contribute significantly to apoptotic, autophagic, and macropinocytotic pathways. Elevated expression levels of Phafin1 and Phafin2 are observed in various cancers. A recent study highlights a significant increase in Phafin1 protein levels in the lungs of idiopathic pulmonary fibrosis patients compared to normal subjects, suggesting a crucial role for Phafin1 in the pathogenesis of pulmonary fibrosis. Additionally, phosphatidylinositol-3-phosphate-binding 2 (Pib2), a close relative of the Phafin1 protein, functions as an amino acid sensor activating the TOCR1 pathway in yeasts. This review focuses on delineating the involvement of Phafin proteins in cellular signaling and their implications in diseases and briefly discusses the latest research findings concerning Pib2.
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Details
- Title
- The role of Phafin proteins in cell signaling pathways and diseases
- Creators
- Tuoxian Tang - University of PennsylvaniaJing Sun - Drexel UniversityChen Li - Freie Universität Berlin
- Publication Details
- Open life sciences, v 19(1), 20220896
- Publisher
- De Gruyter
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:001255096800001
- Scopus ID
- 2-s2.0-85197519614
- Other Identifier
- 991022202513804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biology